Dasanix Tablet 20 mg contains Dasatinib, a potent oral tyrosine kinase inhibitor (TKI) used in the treatment of certain types of leukemia. It is primarily indicated for Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). This lower-strength formulation is particularly useful for dose adjustment, maintenance therapy, or use in patients who require reduced dosing due to tolerability or clinical conditions.

Dasatinib helps control the growth and spread of cancer cells by targeting specific enzymes involved in cell proliferation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Dasatinib 20 mg

Mechanism of Action

Dasatinib inhibits multiple tyrosine kinases, including the BCR-ABL kinase produced by the Philadelphia chromosome abnormality. By blocking this enzyme, it prevents the signaling pathways responsible for the uncontrolled growth of leukemic cells. It also inhibits SRC family kinases, contributing to its broad anticancer activity.

Indications

Dasanix Tablet 20 mg is indicated for:

• Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
• Patients resistant or intolerant to previous therapies such as imatinib
• Dose adjustment and maintenance therapy in leukemia patients

Dosage and Administration

• Taken orally as prescribed by a healthcare professional
• Can be taken with or without food
• Tablets should be swallowed whole; do not crush or chew
• Dosage is individualized based on disease condition, response, and tolerance
• Regular monitoring of blood counts and patient condition is essential

Contraindications

Dasanix Tablet should not be used in:

• Known hypersensitivity to Dasatinib
• Severe hepatic impairment without medical supervision
• Pregnancy and breastfeeding unless advised by a specialist

Side Effects

Common and serious side effects include:

• Bone marrow suppression (anemia, neutropenia, thrombocytopenia)
• Fluid retention (pleural effusion, edema)
• Diarrhea
• Headache
• Fatigue
• Skin rash
• Bleeding disorders
• QT prolongation (heart rhythm abnormalities)

Precautions

• Regular monitoring of complete blood counts is required
• Watch for signs of fluid retention and respiratory symptoms
• Use cautiously in patients with heart or liver disease
• Monitor electrolyte levels during therapy
• Avoid drugs that prolong QT interval unless prescribed
• Should be used under oncologist supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Dasanix Tablet may interact with:

• CYP3A4 inhibitors or inducers
• Antacids and proton pump inhibitors (may reduce absorption)
• Anticoagulants (increased bleeding risk)
• Antiarrhythmic medications

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.