Dasanix Tablet 100 mg contains Dasatinib, a potent oral tyrosine kinase inhibitor (TKI) used in the treatment of specific types of leukemia. It is primarily indicated for Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib works by targeting abnormal proteins responsible for uncontrolled cancer cell growth, helping to slow or stop disease progression.

This higher-strength formulation is commonly used in standard dosing regimens for adult patients under oncologist supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Dasatinib 100 mg

Mechanism of Action

Dasatinib inhibits multiple tyrosine kinases, including the BCR-ABL kinase produced by the Philadelphia chromosome. By blocking this enzyme, it interferes with the signaling pathways that promote the proliferation and survival of leukemic cells. It also inhibits SRC family kinases and other pathways involved in tumor growth and progression.

Indications

Dasanix Tablet 100 mg is indicated for:

• Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic, accelerated, or blast phase
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
• Patients resistant or intolerant to prior therapies such as imatinib
• First-line therapy in selected CML patients as recommended by a specialist

Dosage and Administration

• To be taken orally as prescribed by a healthcare professional
• Can be taken with or without food
• Tablets should be swallowed whole; do not crush or chew
• Dosage varies depending on disease phase and patient response
• Regular monitoring of blood counts and clinical condition is required

Contraindications

Dasanix Tablet should not be used in:

• Known hypersensitivity to Dasatinib
• Severe hepatic impairment without proper medical supervision
• Pregnancy and breastfeeding unless clearly advised by a physician

Side Effects

Common and serious side effects include:

• Bone marrow suppression (anemia, neutropenia, thrombocytopenia)
• Fluid retention (pleural effusion, peripheral edema)
• Diarrhea
• Headache
• Fatigue
• Skin rash
• Bleeding complications
• QT interval prolongation (cardiac arrhythmia risk)

Precautions

• Regular monitoring of complete blood counts is essential
• Monitor for signs of fluid retention or breathing difficulty
• Use cautiously in patients with cardiac or liver conditions
• Electrolyte levels should be checked periodically
• Avoid concurrent use of drugs that prolong QT interval unless prescribed
• Should only be used under oncologist supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Dasanix Tablet may interact with:

• CYP3A4 inhibitors or inducers
• Antacids and proton pump inhibitors (may reduce absorption)
• Anticoagulants (increased bleeding risk)
• Antiarrhythmic drugs

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.