Darvoni Tablet 60 mg+400 mg is a combination antiviral medication containing Daclatasvir and Sofosbuvir, used for the treatment of chronic Hepatitis C virus (HCV) infection. This combination therapy is highly effective in inhibiting viral replication and is commonly prescribed for multiple HCV genotypes.

Darvoni offers a well-tolerated, oral treatment option that significantly improves cure rates when taken as prescribed.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Daclatasvir 60 mg
• Sofosbuvir 400 mg

Mechanism of Action

Darvoni combines two direct-acting antivirals with complementary mechanisms:

• Daclatasvir inhibits the NS5A protein, which is essential for viral replication and assembly.
• Sofosbuvir is a nucleotide analog that inhibits the NS5B RNA-dependent RNA polymerase, blocking viral RNA synthesis.

Together, these agents disrupt different stages of the Hepatitis C virus life cycle, leading to rapid reduction in viral load and eventual viral clearance.

Indications

Darvoni Tablet is indicated for:

• Chronic Hepatitis C virus (HCV) infection
• HCV genotypes 1, 2, 3, and 4 (depending on treatment protocol)
• Patients with or without cirrhosis (as prescribed)
• Patients who are treatment-naïve or experienced
• Combination therapy for improved antiviral response

Dosage and Administration

• Taken orally once daily as prescribed by a healthcare professional
• Can be taken with or without food
• Treatment duration typically ranges from 12 to 24 weeks
• Adherence to the full course is essential for achieving sustained virologic response (SVR)
• Dose adjustments may be required based on clinical condition

Contraindications

Darvoni Tablet should not be used in:

• Known hypersensitivity to Daclatasvir, Sofosbuvir, or any excipients
• Concomitant use with strong enzyme inducers (e.g., rifampicin)
• Pregnancy when used with certain combination regimens unless advised by a physician
• Severe drug interactions without medical supervision

Side Effects

Common side effects may include:

• Headache
• Fatigue
• Nausea
• Insomnia
• Diarrhea
• Mild anemia (in combination with other agents)

Serious side effects are rare but depend on combination therapy and patient condition.

Precautions

• Liver function should be monitored during treatment
• Screening for hepatitis B virus (HBV) is recommended before starting therapy
• Strict adherence is essential to prevent resistance
• Use cautiously in patients with advanced liver disease
• Avoid alcohol to reduce liver strain

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Darvoni Tablet may interact with:

• Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine)
• Certain anticonvulsants
• HIV medications (dose adjustments may be required)
• Proton pump inhibitors (may affect absorption)

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.