Daprosis Tablet 4 mg contains Daprodustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) used for the treatment of anemia associated with chronic kidney disease (CKD). It helps stimulate the body’s natural production of erythropoietin, leading to increased red blood cell formation and improved hemoglobin levels. This lower-strength formulation is useful for dose titration and maintenance therapy under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Daprodustat 4 mg

Mechanism of Action

Daprodustat inhibits hypoxia-inducible factor prolyl hydroxylase enzymes, resulting in stabilization of hypoxia-inducible factor (HIF). This promotes endogenous erythropoietin production in the kidneys and liver, enhances iron utilization, and stimulates red blood cell production in the bone marrow. As a result, it helps correct anemia in patients with chronic kidney disease.

Indications

Daprosis Tablet 4 mg is indicated for:

• Anemia associated with chronic kidney disease (CKD) in adults
• Patients undergoing dialysis or not on dialysis (as prescribed)
• Maintenance therapy after initial correction of hemoglobin levels
• Alternative to injectable erythropoiesis-stimulating agents

Dosage and Administration

• To be taken orally as prescribed by a healthcare professional
• Dosage is individualized based on hemoglobin levels and patient response
• Can be taken with or without food
• Regular monitoring of hemoglobin is required
• Dose adjustments should be made gradually to maintain target hemoglobin levels

Contraindications

Daprosis Tablet should not be used in:

• Known hypersensitivity to Daprodustat
• Uncontrolled hypertension
• Active malignancy unless benefits outweigh risks
• Pregnancy and breastfeeding unless advised by a physician

Side Effects

Possible side effects include:

• Increased blood pressure
• Headache
• Nausea
• Diarrhea
• Peripheral edema
• Dizziness
• Increased risk of thromboembolic events if hemoglobin rises excessively

Precautions

• Monitor hemoglobin levels regularly during therapy
• Ensure blood pressure is well controlled before initiating treatment
• Use cautiously in patients with cardiovascular disease
• Assess and maintain adequate iron levels
• Should be used only under medical supervision in CKD patients

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Daprosis Tablet may interact with:

• CYP enzyme inhibitors or inducers (may alter drug levels)
• Iron supplements (often used alongside therapy)
• Antihypertensive medications
• Anticoagulants (monitoring may be required)

Storage Conditions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.