Daomin XR Tablet 1000 mg is an extended-release (XR) formulation of Metformin Hydrochloride, a widely used oral antidiabetic medication for the management of type 2 diabetes mellitus. Belonging to the biguanide class, Metformin works by reducing glucose production in the liver, enhancing insulin sensitivity, and improving peripheral glucose uptake. The XR formulation allows for controlled, gradual release of the drug over 24 hours, ensuring stable blood glucose levels, improved patient adherence, and minimized gastrointestinal side effects compared to immediate-release tablets. Daomin XR Tablet 1000 mg is suitable for adults and adolescents over 10 years and is often prescribed as a first-line therapy in type 2 diabetes, especially for patients requiring higher doses or once-daily dosing for convenience.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metformin Hydrochloride 1000 mg (Extended-Release)

• Dosage Form: Oral tablet (Extended-Release)

• Route of Administration: Oral

Mechanism of Action

Metformin Hydrochloride lowers blood glucose through multiple mechanisms:

1. Reduction of hepatic glucose production: Inhibits gluconeogenesis in the liver, reducing fasting blood glucose levels.

2. Improved insulin sensitivity: Enhances glucose uptake in skeletal muscle and adipose tissues.

3. Reduction of intestinal glucose absorption: Slightly decreases glucose absorption from the gastrointestinal tract.

Because Metformin does not stimulate insulin secretion, the risk of hypoglycemia is minimal when used as monotherapy. The extended-release formulation maintains steady therapeutic levels, reducing peaks and troughs in blood glucose and improving tolerability.

Indications

Daomin XR Tablet 1000 mg is indicated for:

• Management of type 2 diabetes mellitus in adults and adolescents over 10 years

• Patients who do not achieve adequate glycemic control with diet and lifestyle measures alone

• Use as monotherapy or in combination with other oral antidiabetic agents or insulin

• Obese patients or those with insulin resistance

• Prevention of long-term diabetic complications such as cardiovascular disease, nephropathy, neuropathy, and retinopathy

Dosage and Administration

• Starting dose: 500–1000 mg once daily with the evening meal to minimize gastrointestinal side effects

• The dose may be increased based on blood glucose monitoring, up to a maximum of 2000–2500 mg per day in divided doses

• Swallow tablets whole; do not crush, chew, or break XR tablets to maintain extended-release properties

• Maintain consistent diet, exercise, and blood glucose monitoring for optimal control

Contraindications

Daomin XR Tablet 1000 mg should not be used in:

• Patients with hypersensitivity to Metformin or other biguanides

• Severe renal impairment or acute kidney injury

• Conditions associated with hypoxia, such as severe heart failure or respiratory insufficiency

• Hepatic impairment or chronic alcohol abuse

• Diabetic ketoacidosis or lactic acidosis

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor renal function regularly to prevent lactic acidosis

• Use cautiously in elderly patients or those with risk factors for hypoxia

• Temporarily discontinue before radiologic procedures involving iodinated contrast agents

• Inform your physician of all medications to prevent potential drug interactions

Possible Side Effects

Daomin XR Tablet is generally well tolerated. Common side effects may include:

• Mild gastrointestinal disturbances: nausea, vomiting, diarrhea, or abdominal discomfort

• Metallic taste in the mouth

• Rare but serious: lactic acidosis, especially in patients with renal impairment

Storage

Store below 30°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Conclusion

Daomin XR Tablet 1000 mg provides effective, safe, and convenient glycemic control in patients with type 2 diabetes mellitus. Its extended-release formulation ensures stable blood sugar levels, reduces gastrointestinal side effects, and improves patient compliance with once-daily dosing. When combined with diet, exercise, and regular monitoring, Daomin XR Tablet 1000 mg is a reliable choice for long-term diabetes management.