Cytabin Injection 100 mg/vial contains Cytarabine, an antimetabolite chemotherapy medicine widely used in the treatment of blood-related cancers. It is a key drug in many standard oncology protocols, especially for leukemia management. Cytarabine works by inhibiting DNA synthesis in rapidly dividing malignant cells, thereby slowing or stopping cancer progression.

This lower-strength formulation is suitable for dose-adjusted therapy, pediatric use, and combination chemotherapy regimens under strict hospital supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cytarabine 100 mg

Mechanism of Action

Cytarabine is a pyrimidine nucleoside analog that is converted inside the body into its active form, cytarabine triphosphate. This active metabolite inhibits DNA polymerase, an enzyme essential for DNA replication. By blocking DNA synthesis, Cytarabine prevents cell division, particularly in rapidly proliferating cells such as leukemia cells in the bone marrow.

Indications

Cytabin Injection 100 mg/vial is indicated for the treatment of:

• Acute myeloid leukemia (AML)
• Acute lymphoblastic leukemia (ALL)
• Chronic myelogenous leukemia (blast crisis phase)
• Non-Hodgkin lymphoma (as part of combination therapy)
• Meningeal leukemia (in specialized intrathecal protocols)
• Other hematological malignancies as per oncology guidelines

Dosage and Administration

• Administered only under supervision of a qualified healthcare professional
• Routes include intravenous (IV), subcutaneous (SC), or intrathecal administration in specialized cases
• Dosage depends on body surface area, disease type, and treatment protocol
• Pediatric dosing is strictly weight-based and carefully calculated
• Frequent blood count monitoring is required during therapy
• Dose adjustments may be necessary in hepatic or renal impairment
• Intrathecal use should only be performed by trained oncology specialists

Contraindications

Cytabin Injection should not be used in:

• Patients with known hypersensitivity to Cytarabine
• Severe bone marrow suppression unless part of controlled chemotherapy regimen
• Active uncontrolled infections without appropriate treatment
• Pregnancy and breastfeeding unless clearly directed by a specialist

Side Effects

Possible side effects include:

• Bone marrow suppression (low white cells, red cells, and platelets)
• Nausea, vomiting, and loss of appetite
• Fever and fatigue
• Mouth ulcers (stomatitis)
• Liver function abnormalities
• Hair loss (alopecia)
• Neurological toxicity at high doses (ataxia, dizziness)
• Injection site reactions

Precautions

• Regular monitoring of complete blood count is essential
• Use cautiously in elderly patients and those with liver or kidney impairment
• Increased risk of infections due to immunosuppression
• Neurological monitoring is required in high-dose therapy
• Strict aseptic technique is mandatory during administration
• Hospital setting use only is recommended

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Cytabin Injection may interact with:

• Other myelosuppressive drugs (increased toxicity)
• Digoxin (reduced effectiveness)
• Immunosuppressants (additive immune suppression)
• Fluorocytosine (reduced antifungal efficacy)

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.