Covista Tablet combines Sacubitril 49 mg and Valsartan 51 mg to provide effective management of chronic heart failure with reduced ejection fraction (HFrEF). As an ARNI (Angiotensin Receptor-Neprilysin Inhibitor), Covista works through a dual mechanism: Sacubitril enhances levels of natriuretic peptides, promoting vasodilation and sodium excretion, while Valsartan blocks angiotensin II receptors, reducing vasoconstriction and lowering blood pressure. This combination improves heart efficiency, alleviates symptoms of heart failure, and decreases the risk of hospitalization and cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Covista Tablet 49 mg + 51 mg is indicated for:

• Treatment of chronic heart failure with reduced ejection fraction (HFrEF)
• Reducing the risk of cardiovascular death and hospitalization in heart failure patients
• Patients who remain symptomatic despite standard therapy with ACE inhibitors or other heart failure medications

Mechanism of Action

• Sacubitril: Inhibits neprilysin, increasing natriuretic peptides, which dilate blood vessels, reduce fluid retention, and decrease cardiac workload.
• Valsartan: Blocks AT1 receptors of angiotensin II, preventing vasoconstriction and lowering blood pressure.
• Combined Effect: Improves heart function, reduces symptoms such as breathlessness and fatigue, and helps prevent heart failure progression.

Dosage and Administration

• Take one tablet twice daily, or as prescribed by a physician
• Swallow the tablet whole with water
• Can be taken with or without food
• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended
• Dose adjustments may be needed in patients with renal or hepatic impairment

Benefits

• Improves symptoms of chronic heart failure, including breathlessness, fatigue, and fluid retention
• Reduces the risk of cardiovascular death and hospitalization
• Enhances cardiac efficiency through dual action on neprilysin and angiotensin II pathways
• Convenient twice-daily dosing for long-term management
• Suitable for patients not adequately controlled with other therapies

Side Effects

Common side effects may include:

• Low blood pressure (hypotension)
• Dizziness or lightheadedness
• Elevated potassium levels (hyperkalemia)
• Mild cough

Rare but serious side effects:

• Kidney impairment
• Angioedema (swelling of face, lips, tongue, or throat)
• Severe hypotension

Seek immediate medical attention if severe or persistent side effects occur.

Precautions

• Do not use with ACE inhibitors or within 36 hours of an ACE inhibitor dose
• Monitor renal function and serum electrolytes regularly
• Use caution in patients with kidney or liver impairment
• Inform your physician if pregnant, planning pregnancy, or breastfeeding
• Avoid abrupt discontinuation without medical guidance

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Contraindicated; may harm the fetus
• Lactation: Consult a physician before use
• Elderly: Monitor for hypotension and kidney function
• Renal or hepatic impairment: Dose adjustment may be necessary

Storage

• Store below 30°C
• Keep in a dry, cool place protected from light
• Keep out of reach of children.