Choliva Tablet 5 mg contains Obeticholic Acid, a specialized medication used primarily for managing liver disorders, especially primary biliary cholangitis (PBC). PBC is a chronic autoimmune liver disease characterized by gradual destruction of bile ducts, leading to bile accumulation, liver inflammation, fibrosis, and potential liver failure if left untreated. Choliva helps improve liver function and slow disease progression by regulating bile acid metabolism.

Obeticholic Acid, the active component, is a farnesoid X receptor (FXR) agonist. It works by modulating bile acid synthesis and promoting bile flow, protecting liver cells from damage caused by bile acid accumulation. Choliva 5 mg is often prescribed for patients who are new to Obeticholic Acid therapy or those requiring a lower starting dose to improve tolerance and minimize side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

How Choliva Works

Choliva Tablet 5 mg exerts its therapeutic effects through:

• Activation of FXR: This nuclear receptor in the liver and intestines regulates bile acid production.

• Reduction of bile acid synthesis: Excess bile acids can be toxic to liver cells; Choliva limits their accumulation.

• Improvement of bile acid transport: Enhances excretion of bile acids from the liver into the intestines.

• Anti-inflammatory effect: Reduces liver inflammation and fibrosis over time, protecting liver function.

By addressing the underlying bile acid dysregulation in PBC, Choliva supports long-term liver health and slows disease progression.

Indications

Choliva Tablet 5 mg is indicated for:

• Primary biliary cholangitis (PBC) in adults

• Patients who are inadequate responders or intolerant to ursodeoxycholic acid (UDCA)

• Use as an initial or maintenance therapy under medical supervision for PBC

It is an important component of a comprehensive liver disease management plan, often combined with lifestyle measures and regular monitoring of liver function.

Dosage and Administration

• Usually taken once daily with food to improve absorption

• The 5 mg dose is typically used as the starting dose and may be adjusted based on tolerance and liver function tests

• Regular monitoring of liver enzymes, bilirubin, and cholesterol is recommended

• Do not adjust the dose without consulting your physician

Consistent use as prescribed ensures optimal protection of liver function and maximizes therapeutic benefits.

Precautions and Warnings

Patients should inform their doctor if they have:

• Severe liver impairment or decompensated cirrhosis

• History of liver transplantation

• High cholesterol or triglyceride levels

• Gallbladder disease or biliary obstruction

Common side effects such as pruritus (itching) can occur, especially at the beginning of therapy. Use during pregnancy or breastfeeding should only occur after careful evaluation of benefits versus risks.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Itching (pruritus)

• Fatigue

• Abdominal discomfort or pain

• Nausea

• Joint or muscle pain

Rare but serious adverse effects may involve liver decompensation or severe allergic reactions. Patients experiencing these symptoms should seek medical attention immediately.

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children

Choliva Tablet 5 mg is an effective, well-tolerated option for initiating treatment in primary biliary cholangitis, supporting liver function, reducing bile acid toxicity, and improving long-term liver health.