Certus Tablet 250 mg contains Lapatinib, a targeted anticancer medicine belonging to the class of tyrosine kinase inhibitors (TKIs). It is used mainly in the treatment of HER2-positive breast cancer. Lapatinib works by blocking specific proteins responsible for cancer cell growth, helping slow disease progression and improve treatment outcomes, especially in advanced or metastatic cases.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Lapatinib 250 mg
• Dosage Form: Oral tablet

Mechanism of Action

Lapatinib selectively inhibits the tyrosine kinase activity of two key receptors: HER2 (ErbB2) and EGFR (ErbB1). These receptors are involved in cell growth and survival signaling pathways. By blocking their activity, Lapatinib prevents cancer cell proliferation and induces apoptosis in HER2-overexpressing tumor cells.

Indications

Certus Tablet 250 mg is indicated for:

• HER2-positive metastatic breast cancer
• Advanced or recurrent breast cancer
• Combination therapy with capecitabine or other anticancer agents as prescribed
• Patients who have previously received anthracyclines, taxanes, or trastuzumab

Dosage and Administration

• Must be taken under the supervision of an oncologist
• Dose is determined based on treatment protocol and patient condition
• Usually taken once daily on an empty stomach (as directed)
• Tablets should be swallowed whole with water, not crushed or chewed
• Treatment requires regular monitoring for response and toxicity

Precautions

• Not recommended during pregnancy or breastfeeding
• Liver function should be monitored regularly
• May cause cardiac effects; monitoring may be required in high-risk patients
• Use with caution in patients with gastrointestinal disorders
• Inform physician about all concurrent medications to avoid interactions

Side Effects

Common side effects include:

• Diarrhea
• Nausea and vomiting
• Fatigue
• Rash
• Loss of appetite

Serious side effects:

• Hepatotoxicity (liver injury)
• Cardiac dysfunction
• Severe dehydration from diarrhea
• Interstitial lung disease (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after expiry date

Conclusion

Certus Tablet 250 mg (Lapatinib) is a targeted therapy used in HER2-positive breast cancer. It works by blocking key growth signals in cancer cells, helping slow disease progression and improving patient outcomes under strict oncological supervision.