Camzoy Capsule 5 mg contains Mavacamten, a first-in-class cardiac myosin inhibitor used in the management of symptomatic obstructive hypertrophic cardiomyopathy (HCM). It works by improving heart muscle relaxation and reducing excessive contractility of the left ventricle, thereby improving blood flow and relieving symptoms such as shortness of breath, chest pain, and fatigue.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Mavacamten 5 mg
• Dosage Form: Oral capsule

Mechanism of Action

Mavacamten selectively inhibits cardiac myosin ATPase activity, reducing the formation of excessive actin-myosin cross-bridges in the heart muscle. In hypertrophic cardiomyopathy, this helps decrease hypercontractility and left ventricular outflow tract (LVOT) obstruction, improving cardiac efficiency and symptom control.

Indications

Camzoy Capsule 5 mg is indicated for:

• Symptomatic obstructive hypertrophic cardiomyopathy (oHCM) in adults
• Reduction of left ventricular outflow tract obstruction
• Improvement of exercise capacity and quality of life in HCM patients

Dosage and Administration

• Must be used under the supervision of a cardiologist
• Dose is individualized based on echocardiographic assessment and patient response
• Typically taken once daily
• Regular monitoring of left ventricular ejection fraction (LVEF) is required
• Capsule should be swallowed whole with water

Precautions

• Not recommended in patients with severe systolic heart failure or reduced LVEF below recommended threshold
• Requires regular cardiac monitoring (echocardiography)
• Use with caution in patients with liver impairment
• Avoid use during pregnancy unless clearly necessary
• Drug interactions may occur with CYP2C19 and CYP3A4 inhibitors or inducers

Side Effects

Common side effects include:

• Dizziness
• Fatigue
• Shortness of breath
• Reduced ejection fraction (dose-related)

Serious side effects:

• Heart failure worsening
• Significant reduction in cardiac function
• Arrhythmias (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children
• Do not use after expiry date

Conclusion

Camzoy Capsule 5 mg (Mavacamten) is a novel targeted therapy for obstructive hypertrophic cardiomyopathy. It helps improve heart function by reducing excessive myocardial contractility and LVOT obstruction, offering symptomatic relief and improved quality of life under strict cardiology supervision.