Biva Injection 250 mg/5 ml contains Bivalirudin, a fast-acting anticoagulant (blood thinner) primarily used in patients undergoing certain cardiac procedures. It belongs to a class of medicines known as direct thrombin inhibitors, which help prevent the formation of harmful blood clots.

Bivalirudin is commonly used during procedures like Percutaneous Coronary Intervention (PCI), often referred to as angioplasty. It is especially beneficial for patients with Acute Coronary Syndrome, including unstable angina and myocardial infarction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Bivalirudin 250 mg in 5 ml solution

The injection is intended for intravenous administration and must be given by trained healthcare professionals in a hospital setting.

Mechanism of Action

Bivalirudin works by directly inhibiting thrombin, an essential enzyme in the blood clotting process. Thrombin converts fibrinogen into fibrin, which forms the structural basis of blood clots.

Its action includes:

• Binding directly to thrombin (both free and clot-bound)
• Preventing fibrin formation
• Reducing platelet activation and aggregation
• Minimizing clot development during procedures

This targeted mechanism allows effective anticoagulation with a predictable response.

Indications

Biva Injection is indicated for:

• Patients undergoing Percutaneous Coronary Intervention
• Management of Acute Coronary Syndrome
• Patients at risk of clotting complications during cardiac interventions
• Individuals with or at risk for heparin-induced thrombocytopenia (HIT)

It may be used alone or in combination with other antiplatelet agents.

Dosage and Administration

• Administered as an intravenous bolus followed by infusion
• Dosage depends on body weight and clinical condition
• Given only under continuous medical supervision
• Dose adjustment may be required in patients with kidney impairment

Close monitoring of coagulation parameters is recommended during therapy.

Benefits

Biva Injection offers several advantages:

• Rapid onset and short duration of action
• Predictable anticoagulant effect
• Lower risk of certain complications compared to heparin
• Effective in high-risk cardiac procedures
• Useful alternative in patients with HIT

Possible Side Effects

Some side effects associated with Bivalirudin include:

• Bleeding (most common)
• Back pain
• Nausea
• Low blood pressure
• Headache

Serious bleeding complications, though uncommon, require immediate medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

Before using Biva Injection, inform your doctor if you have:

• Active bleeding or bleeding disorders
• Severe kidney disease
• Recent surgery or trauma
• Uncontrolled hypertension

Caution is advised in elderly patients and those at high risk of bleeding. The safety of Bivalirudin during pregnancy and breastfeeding should be evaluated by a healthcare provider.

Storage

Store at controlled room temperature as directed. Protect from light and moisture. Keep out of reach of children.