Axicef Plus Suspension (125 mg+31.25 mg)/5 ml is a pediatric and adult-friendly oral suspension combining Cefuroxime Axetil 125 mg with Clavulanic Acid 31.25 mg per 5 ml. This combination delivers a broad-spectrum antibacterial effect by pairing a second-generation cephalosporin with a beta-lactamase inhibitor, making it highly effective against resistant bacterial infections.

Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis, resulting in bacterial death, while Clavulanic Acid protects cefuroxime from degradation by beta-lactamase enzymes. This makes Axicef Plus Suspension ideal for respiratory, urinary, skin, and soft tissue infections in children and adults who require an oral liquid form for accurate weight-based dosing and ease of administration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Cefuroxime Axetil 125 mg

• Clavulanic Acid 31.25 mg per 5 ml

Mechanism of Action

Axicef Plus Suspension exerts its effects through a synergistic mechanism:

1. Cefuroxime Axetil:

   • Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

   • Disrupts bacterial cell wall formation, leading to cell lysis and death

   • Effective against Gram-positive and Gram-negative bacteria

2. Clavulanic Acid:

   • Inhibits beta-lactamase enzymes produced by resistant bacteria

   • Protects cefuroxime from enzymatic breakdown

   • Expands the antibacterial spectrum to include beta-lactamase-producing strains

This combination ensures enhanced bacterial eradication, even in infections caused by resistant organisms, improving clinical outcomes.

Indications

Axicef Plus Suspension is indicated for the treatment of:

• Respiratory tract infections: pharyngitis, tonsillitis, sinusitis, bronchitis, and mild pneumonia

• Urinary tract infections: cystitis and pyelonephritis

• Skin and soft tissue infections: cellulitis, abscesses, and wound infections

• Other mild to moderate bacterial infections caused by susceptible organisms

• Pediatric infections where liquid formulation ensures accurate dosing

Benefits

• Broad-Spectrum Antibiotic: Effective against a wide range of bacteria, including resistant strains

• Beta-Lactamase Protection: Clavulanic Acid enhances the activity of cefuroxime against resistant bacteria

• Pediatric-Friendly Formulation: Palatable oral suspension for children and patients who cannot swallow tablets

• Rapid Symptom Relief: Reduces fever, inflammation, and bacterial load efficiently

• Accurate Weight-Based Dosing: Ensures safe and effective therapy for children

• Bactericidal Effect: Actively kills bacteria for effective infection management

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Pediatric dose: 20–30 mg/kg/day of cefuroxime component, divided into two doses, or as prescribed by a healthcare professional

• Shake the bottle well before each use

• Measure the dose using a calibrated measuring spoon or syringe provided with the suspension

• Adults can also use the suspension if needed for ease of administration

• Duration of therapy depends on infection severity, usually 7–14 days

• Complete the full course to prevent recurrence and bacterial resistance

Safety and Precautions

• Common side effects include diarrhea, nausea, vomiting, abdominal pain, and mild rash

• Rare but serious side effects can include allergic reactions, severe diarrhea due to Clostridium difficile, liver enzyme changes, or blood disorders

• Avoid use in patients with hypersensitivity to cephalosporins, penicillins, or Clavulanic Acid

• Use caution in patients with renal or liver impairment; dose adjustments may be necessary

• Pregnant or breastfeeding women should use only under medical supervision

• Inform your healthcare provider about all current medications to prevent potential interactions.