Angivas MR Tablet 35 mg contains Trimetazidine Dihydrochloride, a metabolic agent used to manage angina pectoris (chest pain) and improve heart function. Unlike conventional anti-anginal drugs that primarily affect blood pressure or heart rate, Trimetazidine works at the cellular level by optimizing energy metabolism in cardiac cells. This helps the heart muscle produce energy more efficiently during reduced oxygen supply, which can occur in conditions like chronic stable angina.

The modified-release (MR) formulation ensures a sustained release of the active ingredient, providing consistent therapeutic effects throughout the day and improving patient adherence. Angivas MR helps reduce the frequency and severity of angina attacks and enhances exercise tolerance without significantly affecting heart rate or blood pressure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Reduces frequency and severity of angina attacks
• Improves exercise tolerance and cardiac efficiency
• Works at the cellular level to optimize heart energy metabolism
• Modified-release formulation for consistent 24-hour effect
• Well-tolerated with minimal impact on blood pressure and heart rate

Indications

Angivas MR Tablet is indicated for:

• Chronic stable angina pectoris
• Prevention of angina attacks in patients with coronary artery disease
• Improvement of functional capacity in patients with ischemic heart disease

Mechanism of Action

Trimetazidine acts by selectively inhibiting fatty acid oxidation in cardiac cells, promoting glucose oxidation instead. This shift improves the efficiency of ATP (energy) production in heart muscle cells, especially during ischemic conditions, reducing cellular stress and improving myocardial performance.

Dosage and Administration

• The usual dose is 35 mg once or twice daily as prescribed
• Taken orally with water
• Can be taken with or without food
• Do not crush or chew the modified-release tablet to maintain sustained effect

Side Effects

Common side effects may include:

• Mild gastrointestinal disturbances (nausea, vomiting)
• Headache
• Dizziness
• Fatigue

Rare but serious side effects:

• Parkinsonian symptoms (tremor, rigidity) in susceptible individuals
• Allergic reactions
• Severe hypotension or bradycardia (very rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with Parkinson’s disease or movement disorders
• Regular monitoring recommended in elderly patients
• Not intended for acute angina attacks
• Avoid abrupt discontinuation without consulting a physician

Contraindications

• Hypersensitivity to Trimetazidine or any component of the formulation
• Severe renal impairment (creatinine clearance <30 mL/min)
• Parkinsonian syndromes or other movement disorders

Storage Instructions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.