Amdocal Plus Tablet 5 mg + 50 mg is a combination therapy containing Amlodipine Besilate, a calcium channel blocker, and Atenolol, a selective beta-1 adrenergic blocker. This dual-action formulation is designed for the management of hypertension and angina pectoris, providing complementary mechanisms to control blood pressure and reduce cardiac workload. The combination helps patients achieve better cardiovascular outcomes, especially when monotherapy with either agent alone is insufficient.

Amlodipine works by relaxing vascular smooth muscle, leading to vasodilation and reduced peripheral resistance, while Atenolol decreases heart rate and myocardial contractility, lowering myocardial oxygen demand. Together, they provide effective blood pressure control and symptomatic relief from angina, reducing the risk of cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Amdocal Plus Tablet is indicated for:

• Hypertension: Alone or in combination with other antihypertensive agents

• Chronic stable angina

• Vasospastic (Prinzmetal’s) angina

• Patients requiring dual therapy for better blood pressure and heart rate control

Therapeutic Class

• Calcium Channel Blocker + Beta-Blocker Combination

Pharmacology

Amlodipine Besilate

• Inhibits calcium ion influx in vascular smooth muscle and cardiac muscle

• Causes vasodilation, reducing peripheral vascular resistance and blood pressure

• Reduces myocardial oxygen demand indirectly by lowering afterload

Atenolol

• Selective beta-1 adrenergic blocker

• Reduces heart rate, myocardial contractility, and cardiac output

• Lowers oxygen consumption of the heart, helping prevent angina attacks

Combined Action

• The combination provides enhanced antihypertensive effect by targeting both vascular resistance and cardiac output

• Improves angina symptoms by reducing myocardial oxygen demand and increasing oxygen supply to the heart

• Reduces total ischemic burden in patients with coronary artery disease

Dosage and Administration

Adults:

• Usually 1 tablet once daily, or as directed by a physician

• Dose may be adjusted based on clinical response and tolerability

Special Populations:

• Elderly: Start with standard dose; monitor closely

• Hepatic impairment: Caution advised due to amlodipine metabolism

• Renal impairment: Atenolol dose may need adjustment depending on kidney function

The tablet should be taken with water, with or without food, at the same time each day.

Drug Interactions

Amdocal Plus may interact with:

• Other antihypertensive drugs (may enhance hypotensive effect)

• Antiarrhythmic agents, digoxin, or calcium channel blockers (risk of bradycardia)

• NSAIDs (may reduce antihypertensive effect)

• CYP3A4 inhibitors (may increase amlodipine levels)

• Drugs affecting renal function (may alter atenolol pharmacokinetics)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Severe bradycardia, heart block, or cardiogenic shock

• Known hypersensitivity to Amlodipine, Atenolol, or any excipients

• Severe hypotension

• Decompensated heart failure

Side Effects

Common side effects include:

• Dizziness, headache, fatigue

• Peripheral edema (from amlodipine)

• Bradycardia, cold extremities, hypotension (from atenolol)

• Nausea or gastrointestinal discomfort

Rare but serious effects: severe hypotension, heart block, bronchospasm in susceptible patients

Precautions and Warnings

• Monitor heart rate and blood pressure regularly

• Use with caution in patients with asthma, diabetes, or severe renal/hepatic impairment

• Do not abruptly discontinue therapy; taper under physician guidance to avoid rebound hypertension or angina

Pregnancy and Lactation

• Pregnancy: Use only if clearly needed; risk-benefit must be assessed

• Lactation: Caution advised; Atenolol may pass into breast milk

Storage Conditions

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.