Adair Tablet 500 mcg contains Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor used primarily for chronic obstructive pulmonary disease (COPD) management. Roflumilast works by reducing inflammation in the lungs, decreasing the frequency of exacerbations and improving overall respiratory function.

Unlike bronchodilators, Adair does not provide immediate relief of acute symptoms, but it is highly effective as a maintenance therapy for patients with severe COPD associated with chronic bronchitis and a history of exacerbations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Adair Tablet 500 mcg is indicated for:

• Maintenance treatment of severe COPD associated with chronic bronchitis
• Reduction in the risk of exacerbations in patients with a history of frequent flare-ups
• Adjunct therapy in patients already receiving bronchodilators (long-acting beta-agonists or antimuscarinic agents)

Mechanism of Action

Roflumilast works as a PDE4 inhibitor by:

• Blocking the enzyme phosphodiesterase-4, which breaks down cyclic AMP (cAMP) in inflammatory cells
• Increasing cAMP levels, leading to suppression of inflammatory mediators
• Reducing lung inflammation and mucus production, which helps prevent airway narrowing and flare-ups

This targeted anti-inflammatory action helps improve lung function over time and reduces the frequency of acute COPD exacerbations.

Dosage and Administration

• Recommended dose: 500 mcg once daily, orally, with or without food
• Swallow the tablet whole with water; do not crush or chew
• Continue therapy even if symptoms improve to maintain control of inflammation
• Not intended for immediate relief of sudden shortness of breath or wheezing; use a rescue inhaler if needed
• Regular monitoring of weight, mood, and gastrointestinal symptoms is advised during therapy

Side Effects

Common side effects:

• Diarrhea
• Nausea or vomiting
• Headache
• Weight loss
• Insomnia or sleep disturbances

Rare but serious side effects:

• Severe psychiatric reactions, including depression, anxiety, or suicidal thoughts
• Severe diarrhea leading to dehydration
• Liver enzyme abnormalities

Seek immediate medical attention if severe side effects occur.

Precautions and Warnings

• Not recommended for patients with moderate to severe liver impairment
• Use with caution in patients with a history of depression or psychiatric disorders
• Not intended for treatment of acute COPD attacks
• Pregnancy and breastfeeding: Use only if clearly needed under medical supervision
• Keep out of reach of children

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Adair Tablet may interact with:

• CYP3A4 inducers or inhibitors – may alter roflumilast levels
• Theophylline – monitor for additive side effects
• Other medications causing weight loss or diarrhea – may exacerbate gastrointestinal effects

Inform your doctor about all medications being taken to avoid interactions.

Storage Instructions

• Store at 20–25°C (room temperature)
• Protect from moisture and light
• Keep the tablets in the original container until use
• Keep out of reach of children
• Do not use after the expiry date.