Acmegra Tablet 25 mg contains Sildenafil Citrate, a selective phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction in adult men. Erectile dysfunction is defined as the persistent inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. The 25 mg strength is especially suitable for patients who require a lower starting dose due to increased sensitivity, advanced age, or the presence of certain medical conditions. Acmegra Tablet 25 mg helps improve erectile function by enhancing blood flow to the penile tissue during sexual stimulation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Acmegra Tablet 25 mg is indicated for:

• Treatment of erectile dysfunction in adult males

• Patients requiring a reduced initial dose due to tolerability concerns or drug interactions

Sildenafil does not cause an erection without sexual stimulation and does not increase libido.

Therapeutic Class

Phosphodiesterase type 5 (PDE5) inhibitor

Pharmacology

Sildenafil Citrate works by selectively inhibiting the phosphodiesterase type 5 enzyme, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. Sexual stimulation leads to the release of nitric oxide, increasing cGMP levels and resulting in smooth muscle relaxation and enhanced blood flow to the penis. By preventing the breakdown of cGMP, Sildenafil supports the development and maintenance of an erection. In the absence of sexual arousal, Sildenafil has no therapeutic effect.

Dosage and Administration

The recommended starting dose of Acmegra Tablet is 50 mg taken as needed approximately 30 minutes to 1 hour before sexual activity. However, Acmegra Tablet 25 mg is recommended for patients who require dose reduction, such as:

• Elderly patients

• Patients with hepatic impairment

• Patients with severe renal impairment

• Patients taking potent CYP3A4 inhibitors

• Maximum dosing frequency is once daily

• Tablet should be swallowed whole with water

• May be taken with or without food, though a high-fat meal may delay onset

Dose adjustments should be made based on individual response and tolerability.

Drug Interactions

Acmegra Tablet 25 mg must not be used with nitrates or nitric oxide donors due to the risk of severe hypotension. Caution is required when used with alpha-blockers, antihypertensive agents, and strong CYP3A4 inhibitors such as ritonavir, ketoconazole, and erythromycin. Alcohol may increase the risk of dizziness and hypotension.

Contraindications

Acmegra Tablet 25 mg is contraindicated in patients with:

• Hypersensitivity to Sildenafil Citrate or any excipient

• Concomitant use of organic nitrates

• Severe cardiovascular disorders where sexual activity is inadvisable

• Recent stroke or myocardial infarction

Side Effects

Common adverse effects include headache, flushing, dizziness, nasal congestion, indigestion, and visual disturbances such as blurred vision or color vision changes. Rare but serious side effects may include prolonged erection, sudden hearing loss, severe hypotension, and cardiovascular events.

Precautions and Warnings

Caution should be exercised in patients with cardiovascular disease, anatomical deformities of the penis, bleeding disorders, or active peptic ulcer disease. Medical advice should be sought if chest pain, visual loss, or an erection lasting more than 4 hours occurs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Pregnancy and Lactation

Acmegra Tablet 25 mg is not indicated for use in women. Safety in pregnancy and lactation has not been established.

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.