Aciphin Injection 250 mg contains Ceftriaxone Sodium, a broad-spectrum third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to cell death. Ceftriaxone is effective against both Gram-positive and Gram-negative bacteria and is commonly used in hospital and outpatient settings for infections of the respiratory tract, urinary tract, skin, bones, joints, and certain systemic infections.

Aciphin is formulated for intravenous or intramuscular administration, allowing rapid therapeutic action and high bioavailability, making it suitable for both mild and severe infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Aciphin Injection 250 mg is indicated for the treatment of:

• Respiratory tract infections, including pneumonia and bronchitis
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Meningitis caused by susceptible bacteria
• Septicemia and other systemic bacterial infections
• Gonorrhea and other sexually transmitted infections caused by susceptible strains

Mechanism of Action

Ceftriaxone is a beta-lactam antibiotic that works by:

• Inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins
• Causing bacterial cell lysis and death
• Providing broad-spectrum activity against a wide range of pathogenic bacteria

It is bactericidal and effective against both aerobic and anaerobic organisms.

Dosage and Administration

• Adults: 250 mg to 2 g daily depending on infection severity; may be given as a single dose or divided doses.
• Children: Dose is calculated according to body weight.
• Administer via intravenous infusion or intramuscular injection as advised by a healthcare professional.
• For IM injection, reconstitute with a suitable sterile solution. For IV infusion, dilute in 50–100 ml of compatible fluid and infuse over 30 minutes.
• Complete the full prescribed course even if symptoms improve to prevent bacterial resistance.

Side Effects

Common side effects include:

• Pain or swelling at the injection site
• Mild diarrhea or nausea
• Rash or itching

Rare but serious side effects:

• Severe allergic reactions, including anaphylaxis
• Hematological changes such as leukopenia or thrombocytopenia
• Liver enzyme abnormalities
• Diarrhea caused by Clostridium difficile infection

Seek immediate medical attention if severe symptoms occur.

Precautions and Warnings

• Use with caution in patients with a history of penicillin or cephalosporin allergy.
• Monitor kidney and liver function during prolonged therapy.
• Adjust dosage in patients with renal or hepatic impairment.
• Not recommended for viral infections such as the common cold or flu.
• Report any signs of severe diarrhea, jaundice, or allergic reactions to a healthcare provider immediately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Aciphin Injection may interact with:

• Aminoglycosides – may increase nephrotoxicity risk
• Anticoagulants – may enhance anticoagulant effect
• Live bacterial vaccines – efficacy may be reduced during therapy
• Loop diuretics – may increase risk of kidney impairment

Always inform your physician about other medications being taken.

Storage Instructions

• Store at 2–8°C (refrigerated)
• Protect from light
• Keep the vial tightly closed until use
• Do not freeze
• Keep out of reach of children.