Abeza Tablet 200 mg contains Abemaciclib, a targeted anticancer medication used primarily in the treatment of certain types of breast cancer. It belongs to a class of drugs known as cyclin-dependent kinase (CDK) 4 and 6 inhibitors. This medicine works by slowing down or stopping the growth of cancer cells by interfering with proteins that control cell division. Abeza is commonly prescribed for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Abeza Tablet is indicated for:

• Treatment of HR-positive, HER2-negative advanced or metastatic breast cancer
• Use in combination with endocrine therapy such as aromatase inhibitors or fulvestrant
• As monotherapy in patients whose disease has progressed after endocrine therapy and chemotherapy

Mechanism of Action

Abemaciclib selectively inhibits CDK4 and CDK6, enzymes that play a crucial role in cell cycle progression. By blocking these enzymes, Abeza prevents cancer cells from transitioning from the G1 phase to the S phase, thereby halting cell division and slowing tumor growth.

Dosage and Administration

• The usual recommended dose is determined by a physician based on the patient’s condition and treatment response.
• It is taken orally, with or without food.
• Tablets should be swallowed whole with water and not crushed, chewed, or broken.
• Dose adjustments may be necessary in case of side effects or liver impairment.

Patients are advised to follow their doctor’s instructions strictly for optimal results.

Side Effects

Common side effects may include:

• Diarrhea
• Nausea and vomiting
• Fatigue
• Decreased appetite
• Abdominal pain
• Neutropenia (low white blood cell count)

Serious but less common side effects:

• Liver function abnormalities
• Blood clots
• Severe infections

If any severe or persistent symptoms occur, medical attention should be sought immediately.

Precautions and Warnings

• Regular monitoring of blood counts and liver function is आवश्यक during treatment.
• Patients with liver or kidney disease should use this medication cautiously.
• Avoid grapefruit or grapefruit juice, as it may increase drug levels in the body.
• Effective contraception should be used during treatment and for a period after stopping the medication.
• Not recommended during pregnancy or breastfeeding due to potential harm to the fetus or infant.

Drug Interactions

Abeza Tablet may interact with:

• Strong CYP3A inhibitors or inducers
• Certain antifungal or antibiotic medications
• Other anticancer therapies

Always inform your healthcare provider about all medications and supplements you are taking.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a dry place
• Keep away from light and moisture
• Keep out of reach of children

Conclusion

Abeza Tablet 200 mg (Abemaciclib) is an effective targeted therapy for managing advanced breast cancer, offering improved disease control when used appropriately. Proper adherence to dosage, monitoring, and medical guidance is essential to achieve the best therapeutic outcomes while minimizing risks.